Receptor subtype discrimination using extensive shape complementary designed interfaces

Discriminating between closely related members of a protein family which differ at a limited number of spatially distant positions is a challenge for drug discovery. We describe an approach for computationally designing binders targeting functional sites with large, shape complementary interfaces to...

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Detalles Bibliográficos
Autores principales: Dang, Luke T., Miao, Yi, Ha, Andrew, Yuki, Kanako, Park, Keunwan, Janda, Claudia Y., Jude, Kevin M., Mohan, Kritika, Ha, Nhi, Vallon, Mario, Yuan, Jenny, Vilches-Moure, José G., Kuo, Calvin J., Garcia, K. Christopher, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582999/
https://www.ncbi.nlm.nih.gov/pubmed/31086346
http://dx.doi.org/10.1038/s41594-019-0224-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582999/
https://www.ncbi.nlm.nih.gov/pubmed/31086346
http://dx.doi.org/10.1038/s41594-019-0224-z

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