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Receptor subtype discrimination using extensive shape complementary designed interfaces
Discriminating between closely related members of a protein family which differ at a limited number of spatially distant positions is a challenge for drug discovery. We describe an approach for computationally designing binders targeting functional sites with large, shape complementary interfaces to...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582999/ https://www.ncbi.nlm.nih.gov/pubmed/31086346 http://dx.doi.org/10.1038/s41594-019-0224-z |