Cargando…

Characterizing the selectivity of ER α-glucosidase inhibitors

The endoplasmic reticulum (ER) contains both α-glucosidases and α-mannosidases which process the N-linked oligosaccharides of newly synthesized glycoproteins and thereby facilitate polypeptide folding and glycoprotein quality control. By acting as structural mimetics, iminosugars can selectively inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Keefe, Sarah, Roebuck, Quentin P, Nakagome, Izumi, Hirono, Shuichi, Kato, Atsushi, Nash, Robert, High, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Regular Manuscripts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583763/ https://www.ncbi.nlm.nih.gov/pubmed/30976784 http://dx.doi.org/10.1093/glycob/cwz029

Ejemplares similares

Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity
por: Kato, Atsushi, et al.
Publicado: (2020)

Correction to: Characterizing the selectivity of ER α-glucosidase inhibitors
Publicado: (2023)

Design of a New α-1-C-Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for β-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation
por: Nakagome, Izumi, et al.
Publicado: (2018)

Analysis of Transglucosylation Products of Aspergillus niger α-Glucosidase that Catalyzes the Formation of α-1,2- and α-1,3-Linked Oligosaccharides
por: Kawano, Atsushi, et al.
Publicado: (2020)

A Novel α-Glucosidase of the Glycoside Hydrolase Family 31 from Aspergillus sojae
por: Kawano, Atsushi, et al.
Publicado: (2019)

Identifying Climatic Drivers of Hybridization with a New Ancestral Niche Reconstruction Method
por: Folk, Ryan A, et al.
Publicado: (2023)

N (α)-arylsulfonyl histamines as selective β-glucosidase inhibitors
por: Salazar, M. O., et al.
Publicado: (2018)

Validation of a Patient-Level Medication Regimen Complexity Index as a Possible Tool to Identify Patients for Medication Therapy Management Intervention
por: Hirsch, Jan D, et al.
Publicado: (2014)

Comparative Review of Approved Melatonin Agonists for the Treatment of Circadian Rhythm Sleep‐Wake Disorders
por: Williams, Wilbur P. (Trey), et al.
Publicado: (2016)

Variation in Cardiovascular Risk Related to Individual Antimuscarinic Drugs Used to Treat Overactive Bladder: A UK Cohort Study
por: Arana, Alejandro, et al.
Publicado: (2018)

Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2
por: Kim, Jong-won, et al.
Publicado: (2018)

Functional analysis of the Helicobacter pullorum N-linked protein glycosylation system
por: Jervis, Adrian J, et al.
Publicado: (2018)

Lipoteichoic acid mediates binding of a Lactobacillus S-layer protein
por: Bönisch, Eva, et al.
Publicado: (2018)

Imaging specific cellular glycan structures using glycosyltransferases via click chemistry
por: Wu, Zhengliang L, et al.
Publicado: (2017)

Absence of a human ortholog of rodent Kupffer cell galactose-binding receptor encoded by the CLEC4f gene
por: Taylor, Maureen E, et al.
Publicado: (2019)

Biophysical analysis of sialic acid recognition by the complement regulator Factor H
por: Schmidt, Christoph Q, et al.
Publicado: (2018)

Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways
por: Gonzalez-Gil, Anabel, et al.
Publicado: (2018)

Serine-rich repeat protein adhesins from Lactobacillus reuteri display strain specific glycosylation profiles
por: Latousakis, Dimitrios, et al.
Publicado: (2018)

Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells
por: Blanas, Athanasios, et al.
Publicado: (2018)

KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions
por: Marella, Mathieu, et al.
Publicado: (2018)

Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development
por: Mahajan, Vinay S, et al.
Publicado: (2019)

Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions
por: Starzonek, Sarah, et al.
Publicado: (2020)

Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2
por: Shajahan, Asif, et al.
Publicado: (2020)

A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family
por: Petit, Daniel, et al.
Publicado: (2020)

Key changes in bovine milk immunoglobulin G during lactation: NeuAc sialylation is a hallmark of colostrum immunoglobulin G N-glycosylation
por: Gazi, Inge, et al.
Publicado: (2023)

DNA Sequences Are as Useful as Protein Sequences for Inferring Deep Phylogenies
por: Kapli, Paschalia, et al.
Publicado: (2023)

Online Phylogenetics with matOptimize Produces Equivalent Trees and is Dramatically More Efficient for Large SARS-CoV-2 Phylogenies than de novo and Maximum-Likelihood Implementations
por: Kramer, Alexander M, et al.
Publicado: (2023)

Espalier: Efficient Tree Reconciliation and Ancestral Recombination Graphs Reconstruction Using Maximum Agreement Forests
por: Rasmussen, David A, et al.
Publicado: (2023)

Phylogenomic Analyses Reveal an Allopolyploid Origin of Core Didymocarpinae (Gesneriaceae) Followed by Rapid Radiation
por: Yang, Lihua, et al.
Publicado: (2023)

Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection
por: Spruit, Cindy M, et al.
Publicado: (2023)

Species Delimitation, Phylogenomics, and Biogeography of Sulawesi Flying Lizards: A Diversification History Complicated by Ancient Hybridization, Cryptic Species, and Arrested Speciation
por: Mcguire, Jimmy A, et al.
Publicado: (2023)

Mitochondrial Genome Evolution in Annelida—A Systematic Study on Conservative and Variable Gene Orders and the Factors Influencing its Evolution
por: Struck, Torsten H, et al.
Publicado: (2023)

Compositionally Constrained Sites Drive Long-Branch Attraction
por: Szánthó, Lénárd L, et al.
Publicado: (2023)

Impacts of Taxon-Sampling Schemes on Bayesian Tip Dating Under the Fossilized Birth-Death Process
por: Luo, Arong, et al.
Publicado: (2023)

Estimation of species divergence times in presence of cross-species gene flow
por: Tiley, George P, et al.
Publicado: (2023)

ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II Exhibiting Antiflaviviral Activity
por: Kiappes, J. L., et al.
Publicado: (2017)

Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances
por: Li, Gen, et al.
Publicado: (2015)

Inhibitory Mechanism of Quercimeritrin as a Novel α-Glucosidase Selective Inhibitor
por: Guo, Fengyu, et al.
Publicado: (2023)

α-Glucosidase inhibitors and their use in clinical practice
por: Derosa, Giuseppe, et al.
Publicado: (2012)

α-Glucosidase Inhibitors from Vauquelinia corymbosa
por: Flores-Bocanegra, Laura, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kvb3r1fa1fl73nftln3aefld4b