CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome

Multiple genome-wide studies have identified associations between outcome of HIV infection and polymorphisms in/around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these associations, rs1015164 A/G, is unknown. We found that rs1015164, located 34KB downst...

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Detalles Bibliográficos
Autores principales: Kulkarni, Smita, Lied, Alexandra, Kulkarni, Viraj, Rucevic, Marijana, Martin, Maureen P., Walker-Sperling, Victoria, Anderson, Stephen K., Ewy, Rodger, Singh, Sukhvinder, Nguyen, Hoang, McLaren, Paul J., Viard, Mathias, Naranbhai, Vivek, Zou, Chengcheng, Lin, Zhansong, Gatanaga, Hiroyuki, Oka, Shinichi, Takiguchi, Masafumi, Thio, Chloe L., Margolick, Joseph, Kirk, Gregory D., Goedert, James J., Hoots, W. Keith, Deeks, Steven G., Haas, David W., Michael, Nelson, Walker, Bruce, Le Gall, Sylvie, Chowdhury, Fatema Z., Yu, Xu G., Carrington, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584055/
https://www.ncbi.nlm.nih.gov/pubmed/31209403
http://dx.doi.org/10.1038/s41590-019-0406-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584055/
https://www.ncbi.nlm.nih.gov/pubmed/31209403
http://dx.doi.org/10.1038/s41590-019-0406-1

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