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Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice

Reelin (Reln) and Disabled-1 (Dab1) participate in the Reln-signaling pathway and when either is deleted, mutant mice have the same spinally mediated behavioral abnormalities, increased sensitivity to noxious heat and a profound loss in mechanical sensitivity. Both Reln and Dab1 are highly expressed...

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Detalles Bibliográficos
Autores principales: Wang, Xidao, Yvone, Griselda M., Cilluffo, Marianne, Kim, Ashley S., Basbaum, Allan I., Phelps, Patricia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584071/
https://www.ncbi.nlm.nih.gov/pubmed/31122949
http://dx.doi.org/10.1523/ENEURO.0131-19.2019