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Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin

Combination chemotherapy is often employed to improve therapeutic efficacies of drugs. However, traditional combination regimens often utilize drugs at or near‐their maximum tolerated doses (MTDs), elevating the risk of dose‐related toxicity and impeding their clinical success. Further, high doses o...

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Detalles Bibliográficos
Autores principales: Pusuluri, Anusha, Krishnan, Vinu, Wu, Debra, Shields, C. Wyatt, Wang, Li W., Mitragotri, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584462/
https://www.ncbi.nlm.nih.gov/pubmed/31249879
http://dx.doi.org/10.1002/btm2.10129