PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of KIF1C. We show that the microtubule binding surf...

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Detalles Bibliográficos
Autores principales: Siddiqui, Nida, Zwetsloot, Alexander James, Bachmann, Alice, Roth, Daniel, Hussain, Hamdi, Brandt, Jonathan, Kaverina, Irina, Straube, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584639/
https://www.ncbi.nlm.nih.gov/pubmed/31217419
http://dx.doi.org/10.1038/s41467-019-10644-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584639/
https://www.ncbi.nlm.nih.gov/pubmed/31217419
http://dx.doi.org/10.1038/s41467-019-10644-9

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