Cargando…

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of KIF1C. We show that the microtubule binding surf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddiqui, Nida, Zwetsloot, Alexander James, Bachmann, Alice, Roth, Daniel, Hussain, Hamdi, Brandt, Jonathan, Kaverina, Irina, Straube, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584639/ https://www.ncbi.nlm.nih.gov/pubmed/31217419 http://dx.doi.org/10.1038/s41467-019-10644-9

Ejemplares similares

Force generation of KIF1C is impaired by pathogenic mutations
por: Siddiqui, Nida, et al.
Publicado: (2022)

Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
por: Bianchi, Sarah, et al.
Publicado: (2016)

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms
por: Hammond, Jennetta W., et al.
Publicado: (2010)

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge
por: Karasmanis, Eva P., et al.
Publicado: (2023)

Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A
por: Cong, Dezi, et al.
Publicado: (2021)

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint
por: Combes, Guillaume, et al.
Publicado: (2018)

Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
por: Obaji, Ezeogo, et al.
Publicado: (2021)

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition
por: McDonald, Nathan A., et al.
Publicado: (2023)

SAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition
por: McDonald, Nathan A., et al.
Publicado: (2023)

Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8
por: Ye, Yuxin, et al.
Publicado: (2020)

Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells
por: Bracey, Kai M., et al.
Publicado: (2023)

The Shigella Virulence Factor IcsA Relieves N-WASP Autoinhibition by Displacing the Verprolin Homology/Cofilin/Acidic (VCA) Domain
por: Mauricio, Rui P. M., et al.
Publicado: (2017)

Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking
por: Arnette, Christopher, et al.
Publicado: (2016)

Intracellular transport, molecular motors, KIFs and related diseases
por: Hirokawa, Nobutaka
Publicado: (2014)

Novel Dendritic Kinesin Sorting Identified by Different Process Targeting of Two Related Kinesins: KIF21A and KIF21B
por: Marszalek, Joseph R., et al.
Publicado: (1999)

Tuning Protein Autoinhibition by Domain Destabilization
por: Cho, Jae-Hyun, et al.
Publicado: (2011)

Control of mRNA decapping by autoinhibition
por: Paquette, David R, et al.
Publicado: (2018)

DCLK1 autoinhibition and activation in tumorigenesis
por: Cheng, Linna, et al.
Publicado: (2021)

TUBB3 and KIF21A in neurodevelopment and disease
por: Puri, Dharmendra, et al.
Publicado: (2023)

Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C
por: Kendrick, Agnieszka A., et al.
Publicado: (2019)

Prognostic value and immunological role of PTPN21 in pan-cancer analysis
por: Yang, YanE, et al.
Publicado: (2023)

Structural Basis for ESCRT-III Protein Autoinhibition
por: Bajorek, Monika, et al.
Publicado: (2009)

Autoinhibition by Iodide Ion in the Methionine–Iodine Reaction
por: Xu, Li, et al.
Publicado: (2020)

The Architecture of Talin1 Reveals an Autoinhibition Mechanism
por: Dedden, Dirk, et al.
Publicado: (2019)

Allosteric regulation of autoinhibition and activation of c-Abl
por: Liu, Yonglan, et al.
Publicado: (2022)

Structure of LRRK1 and mechanisms of autoinhibition and activation
por: Reimer, Janice M., et al.
Publicado: (2023)

Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains
por: Bor, Batbileg, et al.
Publicado: (2012)

Phosphorylation Controls Autoinhibition of Cytoplasmic Linker Protein-170
por: Lee, Ho-Sup, et al.
Publicado: (2010)

Structure of the human Parkin ligase domain in an autoinhibited state
por: Wauer, Tobias, et al.
Publicado: (2013)

Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
por: Wang, Xin, et al.
Publicado: (2014)

Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
por: Wu, Jing-Xiang, et al.
Publicado: (2015)

Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E
por: Bandyra, Katarzyna J., et al.
Publicado: (2018)

Autoinhibition of TRPV6 Channel and Regulation by PIP2
por: Cai, Ruiqi, et al.
Publicado: (2020)

Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
por: Page, Dana A., et al.
Publicado: (2020)

Cryo-EM structure of the autoinhibited state of myosin-2
por: Heissler, Sarah M., et al.
Publicado: (2021)

PH domain-mediated autoinhibition and oncogenic activation of Akt
por: Bae, Hwan, et al.
Publicado: (2022)

Autoinhibited transient, gated, and cascaded dynamic transcription of RNAs
por: Li, Zhenzhen, et al.
Publicado: (2022)

Molecular architecture of the autoinhibited kinesin-1 lambda particle
por: Weijman, Johannes F., et al.
Publicado: (2022)

Abundant kif21b is associated with accelerated progression in neurodegenerative diseases
por: Kreft, Karim L, et al.
Publicado: (2014)

PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo
por: Campbell, Jennie S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qqk8g688ljiko29tkvia6ldfqc