FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth

Liver kinase B1 (LKB1) regulates both cell growth and energy metabolism. Inactivated mutations of LKB1, observed in 20–30% of nonsmall cell lung cancers (NSCLC), contribute significantly to lung cancer malignancy progression. However, the upstream signalings regulating LKB1 activity remain incomplet...

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Detalles Bibliográficos
Autores principales: Zhu, Xiao-Na, He, Ping, Zhang, Liang, Yang, Shuo, Zhang, Hui-Lin, Zhu, Di, Liu, Meng-Di, Yu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584689/
https://www.ncbi.nlm.nih.gov/pubmed/31217475
http://dx.doi.org/10.1038/s41419-019-1732-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584689/
https://www.ncbi.nlm.nih.gov/pubmed/31217475
http://dx.doi.org/10.1038/s41419-019-1732-9

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