Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment

Limitation of 5-fluorouracil (5-FU) anticancer efficacy is due to IL-1β secretion by myeloid-derived suppressor cells (MDSC), according to a previous pre-clinical report. Release of mature IL-1β is a consequence of 5-FU-mediated NLRP3 activation and subsequent caspase-1 activity in MDSC. IL-1β susta...

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Detalles Bibliográficos
Autores principales: Dumont, Adélie, de Rosny, Charlotte, Kieu, Trinh-Le-Vi, Perrey, Sabrina, Berger, Hélène, Fluckiger, Aurélie, Muller, Tania, Pais de Barros, Jean-Paul, Pichon, Laurent, Hichami, Aziz, Thomas, Charles, Rébé, Cédric, Ghiringhelli, François, Rialland, Mickaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584690/
https://www.ncbi.nlm.nih.gov/pubmed/31217433
http://dx.doi.org/10.1038/s41419-019-1723-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584690/
https://www.ncbi.nlm.nih.gov/pubmed/31217433
http://dx.doi.org/10.1038/s41419-019-1723-x

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