LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells

Non-small-cell lung carcinoma (NSCLC) continues to be a vital disease worldwide for its high incidence and consequent mortality rate. In this study, we investigated the anti-cancer effect of LZ-101, a new derivative of danofloxacin, against non-small-cell lung cancer and the underlying mechanisms. I...

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Detalles Bibliográficos
Autores principales: Guo, Yongjian, Zhao, Yue, Zhou, Yuxin, Tang, Xiaoqing, Li, Zhiyu, Wang, Xiaotang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584698/
https://www.ncbi.nlm.nih.gov/pubmed/31217472
http://dx.doi.org/10.1038/s41419-019-1714-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584698/
https://www.ncbi.nlm.nih.gov/pubmed/31217472
http://dx.doi.org/10.1038/s41419-019-1714-y

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