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LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells

Non-small-cell lung carcinoma (NSCLC) continues to be a vital disease worldwide for its high incidence and consequent mortality rate. In this study, we investigated the anti-cancer effect of LZ-101, a new derivative of danofloxacin, against non-small-cell lung cancer and the underlying mechanisms. I...

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Detalles Bibliográficos
Autores principales:	Guo, Yongjian, Zhao, Yue, Zhou, Yuxin, Tang, Xiaoqing, Li, Zhiyu, Wang, Xiaotang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584698/ https://www.ncbi.nlm.nih.gov/pubmed/31217472 http://dx.doi.org/10.1038/s41419-019-1714-y

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