Cargando…

Replication fork rescue in mammalian mitochondria

Replication stalling has been associated with the formation of pathological mitochondrial DNA (mtDNA) rearrangements. Yet, almost nothing is known about the fate of stalled replication intermediates in mitochondria. We show here that replication stalling in mitochondria leads to replication fork reg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torregrosa-Muñumer, Rubén, Hangas, Anu, Goffart, Steffi, Blei, Daniel, Zsurka, Gábor, Griffith, Jack, Kunz, Wolfram S., Pohjoismäki, Jaakko L. O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584726/ https://www.ncbi.nlm.nih.gov/pubmed/31217442 http://dx.doi.org/10.1038/s41598-019-45244-6

Ejemplares similares

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift
por: Torregrosa-Muñumer, Rubén, et al.
Publicado: (2015)

Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance
por: Goffart, Steffi, et al.
Publicado: (2019)

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2
por: Hangas, Anu, et al.
Publicado: (2018)

Top3α is the replicative topoisomerase in mitochondrial DNA replication
por: Hangas, Anu, et al.
Publicado: (2022)

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks
por: Pohjoismäki, Jaakko L. O., et al.
Publicado: (2009)

TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts
por: Aasumets, Koit, et al.
Publicado: (2021)

Developmental and Pathological Changes in the Human Cardiac Muscle Mitochondrial DNA Organization, Replication and Copy Number
por: Pohjoismäki, Jaakko L. O., et al.
Publicado: (2010)

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes
por: Wanrooij, Sjoerd, et al.
Publicado: (2007)

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
por: Doimo, Mara, et al.
Publicado: (2023)

EEPD1: Breaking and Rescuing the Replication Fork
por: Liu, Yilun
Publicado: (2016)

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication
por: Rahman, Md. Mostafijur, et al.
Publicado: (2022)

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
por: Peeva, Viktoriya, et al.
Publicado: (2018)

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells
por: Pohjoismäki, Jaakko L. O., et al.
Publicado: (2006)

Uncharacterized protein C17orf80 – a novel interactor of human mitochondrial nucleoids
por: Potter, Alisa, et al.
Publicado: (2023)

The Type and Source of Reactive Oxygen Species Influences the Outcome of Oxidative Stress in Cultured Cells
por: Goffart, Steffi, et al.
Publicado: (2021)

DNA Replication Origins and Fork Progression at Mammalian Telomeres
por: Higa, Mitsunori, et al.
Publicado: (2017)

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response
por: Pohjoismäki, Jaakko L. O., et al.
Publicado: (2012)

Replication fork regression in repetitive DNAs
por: Fouché, Nicole, et al.
Publicado: (2006)

Single-molecule insight into stalled replication fork rescue in Escherichia coli
por: Bianco, Piero R, et al.
Publicado: (2021)

Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?
por: Zsurka, Gábor, et al.
Publicado: (2018)

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
por: Sotiriou, Sotirios K., et al.
Publicado: (2016)

Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage
por: Pond, Kelvin W., et al.
Publicado: (2019)

Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase
por: Whinn, Kelsey S, et al.
Publicado: (2023)

Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription
por: Brambati, Alessandra, et al.
Publicado: (2018)

Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue
por: Appanah, Rowin, et al.
Publicado: (2020)

Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork
por: van Pel, Derek M., et al.
Publicado: (2013)

Establishment of a replication fork barrier following induction of DNA binding in mammalian cells
por: Beuzer, Paolo, et al.
Publicado: (2014)

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks
por: Willis, Nicholas A., et al.
Publicado: (2014)

Replication fork instability and the consequences of fork collisions from rereplication
por: Alexander, Jessica L., et al.
Publicado: (2016)

Replication Fork Reversal and Protection
por: Qiu, Shan, et al.
Publicado: (2021)

Replication dynamics of recombination-dependent replication forks
por: Naiman, Karel, et al.
Publicado: (2021)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2015)

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
por: Somyajit, Kumar, et al.
Publicado: (2020)

Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery
por: Costes, Audrey, et al.
Publicado: (2012)

RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue
por: Manosas, Maria, et al.
Publicado: (2013)

hCLK2 couples FANCD2 to stalled replication forks and functions in the mammalian S-phase checkpoint
por: Collis, SJ, et al.
Publicado: (2006)

Replication forks, chromatin loops and dormant replication origins
por: Blow, J Julian, et al.
Publicado: (2008)

Replication Fork Reversal after Replication–Transcription Collision
por: De Septenville, Anne L., et al.
Publicado: (2012)

Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase
por: Hustedt, Nicole, et al.
Publicado: (2013)

Replication termination without a replication fork trap
por: Galli, Elisa, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9emhu6mq7uco28dm2f2tic3igr