A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

BACKGROUND: Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of LOAD, more than half of the heritability for the disease remains unclear. Althou...

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Detalles Bibliográficos
Autores principales: Asanomi, Yuya, Shigemizu, Daichi, Miyashita, Akinori, Mitsumori, Risa, Mori, Taiki, Hara, Norikazu, Ito, Kaoru, Niida, Shumpei, Ikeuchi, Takeshi, Ozaki, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585023/
https://www.ncbi.nlm.nih.gov/pubmed/31216982
http://dx.doi.org/10.1186/s10020-019-0090-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585023/
https://www.ncbi.nlm.nih.gov/pubmed/31216982
http://dx.doi.org/10.1186/s10020-019-0090-5

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