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Comparison of pathway analysis and constraint-based methods for cell factory design

BACKGROUND: Computational strain optimisation methods (CSOMs) have been successfully used to exploit genome-scale metabolic models, yielding strategies useful for allowing compound overproduction in metabolic cell factories. Minimal cut sets are particularly interesting since their definition allows...

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Detalles Bibliográficos
Autores principales: Vieira, Vítor, Maia, Paulo, Rocha, Miguel, Rocha, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585037/
https://www.ncbi.nlm.nih.gov/pubmed/31221092
http://dx.doi.org/10.1186/s12859-019-2934-y