Increased Complement 3 With Suppression of miR‐145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

BACKGROUND: We previously reported that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) show the increased expression of complement 3 (C3) and the synthetic phenotype. We targeted the SHR C3 gene (C3 knockout [C3KO] SHRs) by the zinc finger gene editing method. In th...

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Detalles Bibliográficos
Autores principales: Chen, Lan, Fukuda, Noboru, Otsuki, Tomoyasu, Tanaka, Sho, Nakamura, Yoshihiro, Kobayashi, Hiroki, Matsumoto, Taro, Abe, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585333/
https://www.ncbi.nlm.nih.gov/pubmed/31070083
http://dx.doi.org/10.1161/JAHA.119.012327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585333/
https://www.ncbi.nlm.nih.gov/pubmed/31070083
http://dx.doi.org/10.1161/JAHA.119.012327

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