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Increased Complement 3 With Suppression of miR‐145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

BACKGROUND: We previously reported that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) show the increased expression of complement 3 (C3) and the synthetic phenotype. We targeted the SHR C3 gene (C3 knockout [C3KO] SHRs) by the zinc finger gene editing method. In th...

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Detalles Bibliográficos
Autores principales:	Chen, Lan, Fukuda, Noboru, Otsuki, Tomoyasu, Tanaka, Sho, Nakamura, Yoshihiro, Kobayashi, Hiroki, Matsumoto, Taro, Abe, Masanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585333/ https://www.ncbi.nlm.nih.gov/pubmed/31070083 http://dx.doi.org/10.1161/JAHA.119.012327

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