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Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved
The pathological implication of amyloid precursor protein (APP) in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide. However, the physiological functions of APP are still poorly understood. APP is considered a multimodal protein due to its...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585543/ https://www.ncbi.nlm.nih.gov/pubmed/31169172 http://dx.doi.org/10.4103/1673-5374.257511 |
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author | Coronel, Raquel Palmer, Charlotte Bernabeu-Zornoza, Adela Monteagudo, María Rosca, Andreea Zambrano, Alberto Liste, Isabel |
author_facet | Coronel, Raquel Palmer, Charlotte Bernabeu-Zornoza, Adela Monteagudo, María Rosca, Andreea Zambrano, Alberto Liste, Isabel |
author_sort | Coronel, Raquel |
collection | PubMed |
description | The pathological implication of amyloid precursor protein (APP) in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide. However, the physiological functions of APP are still poorly understood. APP is considered a multimodal protein due to its role in a wide variety of processes, both in the embryo and in the adult brain. Specifically, APP seems to play a key role in the proliferation, differentiation and maturation of neural stem cells. In addition, APP can be processed through two canonical processing pathways, generating different functionally active fragments: soluble APP-α, soluble APP-β, amyloid-β peptide and the APP intracellular C-terminal domain. These fragments also appear to modulate various functions in neural stem cells, including the processes of proliferation, neurogenesis, gliogenesis or cell death. However, the molecular mechanisms involved in these effects are still unclear. In this review, we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells, as well as the possible signaling pathways that could be implicated in these effects. The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease, and in the search for potential therapeutic targets. |
format | Online Article Text |
id | pubmed-6585543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-65855432019-10-01 Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved Coronel, Raquel Palmer, Charlotte Bernabeu-Zornoza, Adela Monteagudo, María Rosca, Andreea Zambrano, Alberto Liste, Isabel Neural Regen Res Review The pathological implication of amyloid precursor protein (APP) in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide. However, the physiological functions of APP are still poorly understood. APP is considered a multimodal protein due to its role in a wide variety of processes, both in the embryo and in the adult brain. Specifically, APP seems to play a key role in the proliferation, differentiation and maturation of neural stem cells. In addition, APP can be processed through two canonical processing pathways, generating different functionally active fragments: soluble APP-α, soluble APP-β, amyloid-β peptide and the APP intracellular C-terminal domain. These fragments also appear to modulate various functions in neural stem cells, including the processes of proliferation, neurogenesis, gliogenesis or cell death. However, the molecular mechanisms involved in these effects are still unclear. In this review, we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells, as well as the possible signaling pathways that could be implicated in these effects. The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease, and in the search for potential therapeutic targets. Wolters Kluwer - Medknow 2019-10 /pmc/articles/PMC6585543/ /pubmed/31169172 http://dx.doi.org/10.4103/1673-5374.257511 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Coronel, Raquel Palmer, Charlotte Bernabeu-Zornoza, Adela Monteagudo, María Rosca, Andreea Zambrano, Alberto Liste, Isabel Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
title | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
title_full | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
title_fullStr | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
title_full_unstemmed | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
title_short | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
title_sort | physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585543/ https://www.ncbi.nlm.nih.gov/pubmed/31169172 http://dx.doi.org/10.4103/1673-5374.257511 |
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