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Gata3 hypermethylation and Foxp3 hypomethylation are associated with sustained protection and bystander effect following epicutaneous immunotherapy in peanut‐sensitized mice

BACKGROUND: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characteriz...

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Detalles Bibliográficos
Autores principales: Mondoulet, L., Dioszeghy, V., Busato, F., Plaquet, C., Dhelft, V., Bethune, K., Leclere, L., Daviaud, C., Ligouis, M., Sampson, H., Dupont, C., Tost, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585762/
https://www.ncbi.nlm.nih.gov/pubmed/29779209
http://dx.doi.org/10.1111/all.13479