Catalytic enantioselective synthesis of perfluoroalkyl-substituted β-lactones via a concerted asynchronous [2 + 2] cycloaddition: a synthetic and computational study

The enantioselective preparation of a range of perfluoroalkyl-substituted β-lactones through an isothiourea (HyperBTM) catalysed reaction using symmetric anhydrides as ammonium enolate precursors and perfluoroalkylketones (R(F) = CF(3), C(2)F(5), C(4)F(9)) is reported. Following optimisation, high d...

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Detalles Bibliográficos
Autores principales: Barrios Antúnez, Diego-Javier, Greenhalgh, Mark D., Brueckner, Alexander C., Walden, Daniel M., Elías-Rodríguez, Pilar, Roberts, Patrick, Young, Benjamin G., West, Thomas H., Slawin, Alexandra M. Z., Ha-Yeon Cheong, Paul, Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585878/
https://www.ncbi.nlm.nih.gov/pubmed/31360423
http://dx.doi.org/10.1039/c9sc00390h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585878/
https://www.ncbi.nlm.nih.gov/pubmed/31360423
http://dx.doi.org/10.1039/c9sc00390h

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