Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance

A key consideration at the screening stages of drug discovery is in vitro metabolic stability, often measured in human liver microsomes. Computational prediction models can be built using a large quantity of experimental data available from public databases, but these databases typically contain dat...

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Detalles Bibliográficos
Autores principales: Esaki, Tsuyoshi, Watanabe, Reiko, Kawashima, Hitoshi, Ohashi, Rikiya, Natsume‐Kitatani, Yayoi, Nagao, Chioko, Mizuguchi, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586005/
https://www.ncbi.nlm.nih.gov/pubmed/30247811
http://dx.doi.org/10.1002/minf.201800086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586005/
https://www.ncbi.nlm.nih.gov/pubmed/30247811
http://dx.doi.org/10.1002/minf.201800086

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