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Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance
A key consideration at the screening stages of drug discovery is in vitro metabolic stability, often measured in human liver microsomes. Computational prediction models can be built using a large quantity of experimental data available from public databases, but these databases typically contain dat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586005/ https://www.ncbi.nlm.nih.gov/pubmed/30247811 http://dx.doi.org/10.1002/minf.201800086 |