PAX7 target gene repression is a superior FSHD biomarker than DUX4 target gene activation, associating with pathological severity and identifying FSHD at the single-cell level

Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, incurable skeletal myopathy. The condition is linked to hypomethylation of the D4Z4 macrosatellite repeat at chromosome 4q35, leading to epigenetic derepression of the transcription factor DUX4; coupled with a permissive 4qA haplotype sup...

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Detalles Bibliográficos
Autores principales: Banerji, Christopher R S, Zammit, Peter S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586142/
https://www.ncbi.nlm.nih.gov/pubmed/31067297
http://dx.doi.org/10.1093/hmg/ddz043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586142/
https://www.ncbi.nlm.nih.gov/pubmed/31067297
http://dx.doi.org/10.1093/hmg/ddz043

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