Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Bcl-2 family proteins control a decisive apoptotic event: mitochondrial outer membrane permeabilization (MOMP). To discover MOMP-regulating proteins, we expressed a library of intracellular single-chain variable fragments (scFvs) (“intrabodies”) and selected for those rescuing cells from apoptosis i...

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Detalles Bibliográficos
Autores principales: Liu, Tong, Kuwana, Tomomi, Zhang, Hongkai, Vander Heiden, Matthew G., Lerner, Richard A., Newmeyer, Donald D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586363/
https://www.ncbi.nlm.nih.gov/pubmed/31181072
http://dx.doi.org/10.1371/journal.pbio.2004413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586363/
https://www.ncbi.nlm.nih.gov/pubmed/31181072
http://dx.doi.org/10.1371/journal.pbio.2004413

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