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Predicting three-dimensional genome organization with chromatin states

We introduce a computational model to simulate chromatin structure and dynamics. Starting from one-dimensional genomics and epigenomics data that are available for hundreds of cell types, this model enables de novo prediction of chromatin structures at five-kilo-base resolution. Simulated chromatin...

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Detalles Bibliográficos
Autores principales: Qi, Yifeng, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586364/
https://www.ncbi.nlm.nih.gov/pubmed/31181064
http://dx.doi.org/10.1371/journal.pcbi.1007024