miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia

MicroRNA-15a (miR-15a) and miR-16, which are transcribed from the miR-15a/miR-16-1 cluster, inhibit post-ischemic angiogenesis. MicroRNA (miRNA) binding to mRNA coding sequences (CDSs) is a newly emerging mechanism of gene expression regulation. We aimed to (1) identify new mediators of the anti-ang...

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Detalles Bibliográficos
Autores principales: Besnier, Marie, Shantikumar, Saran, Anwar, Maryam, Dixit, Parul, Chamorro-Jorganes, Aranzazu, Sweaad, Walid, Sala-Newby, Graciela, Madeddu, Paolo, Thomas, Anita C., Howard, Lynsey, Mushtaq, Sobia, Petretto, Enrico, Caporali, Andrea, Emanueli, Costanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586592/
https://www.ncbi.nlm.nih.gov/pubmed/31220779
http://dx.doi.org/10.1016/j.omtn.2019.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586592/
https://www.ncbi.nlm.nih.gov/pubmed/31220779
http://dx.doi.org/10.1016/j.omtn.2019.05.002

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