P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

Sepsis is characterized by a systemic inflammatory response followed by immunosuppression of the host. Metabolic defects and mitochondrial failure are common in immunocompromised patients with sepsis. The NLRP3 inflammasome is important for establishing an inflammatory response after activation by t...

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Detalles Bibliográficos
Autores principales: Martínez-García, Juan José, Martínez-Banaclocha, Helios, Angosto-Bazarra, Diego, de Torre-Minguela, Carlos, Baroja-Mazo, Alberto, Alarcón-Vila, Cristina, Martínez-Alarcón, Laura, Amores-Iniesta, Joaquín, Martín-Sánchez, Fátima, Ercole, Giovanni A., Martínez, Carlos M., González-Lisorge, Ada, Fernández-Pacheco, José, Martínez-Gil, Piedad, Adriouch, Sahil, Koch-Nolte, Friedrich, Luján, Juan, Acosta-Villegas, Francisco, Parrilla, Pascual, García-Palenciano, Carlos, Pelegrin, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586640/
https://www.ncbi.nlm.nih.gov/pubmed/31221993
http://dx.doi.org/10.1038/s41467-019-10626-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586640/
https://www.ncbi.nlm.nih.gov/pubmed/31221993
http://dx.doi.org/10.1038/s41467-019-10626-x

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