Single-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography

The engineering of immunoglobulin-G molecules (IgGs) is of wide interest for improving therapeutics, for example by modulating the activity or multiplexing the specificity of IgGs to recognize more than one antigen. Optimization of engineered IgG requires knowledge of three-dimensional (3D) structur...

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Detalles Bibliográficos
Autores principales: Lei, Dongsheng, Liu, Jianfang, Liu, Hongbin, Cleveland, Thomas E., Marino, John P., Lei, Ming, Ren, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586654/
https://www.ncbi.nlm.nih.gov/pubmed/31221961
http://dx.doi.org/10.1038/s41598-019-44978-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586654/
https://www.ncbi.nlm.nih.gov/pubmed/31221961
http://dx.doi.org/10.1038/s41598-019-44978-7

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