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Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding
Protein folding can begin co-translationally. Due to the difference in timescale between folding and synthesis, co-translational folding is thought to occur at equilibrium for fast-folding domains. In this scenario, the folding kinetics of stalled ribosome-bound nascent chains should match the foldi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586675/ https://www.ncbi.nlm.nih.gov/pubmed/31221966 http://dx.doi.org/10.1038/s41467-019-10647-6 |