Cargando…
Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells
Despite advances in stem cell research, cell transplantation therapy for liver failure is impeded by a shortage of human primary hepatocytes (HPH), along with current differentiation protocol limitations. Several studies have examined the concept of co-culture of human induced pluripotent cells (hiP...
Autores principales: | Pettinato, Giuseppe, Lehoux, Sylvain, Ramanathan, Rajesh, Salem, Mohamed M., He, Li-Xia, Muse, Oluwatoyosi, Flaumenhaft, Robert, Thompson, Melissa T., Rouse, Emily A., Cummings, Richard D., Wen, Xuejun, Fisher, Robert A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586904/ https://www.ncbi.nlm.nih.gov/pubmed/31222080 http://dx.doi.org/10.1038/s41598-019-45514-3 |
Ejemplares similares
-
Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition
por: Pettinato, Giuseppe, et al.
Publicado: (2016) -
Pluripotent-Stem-Cell-Derived Hepatic Cells: Hepatocytes and Organoids for Liver Therapy and Regeneration
por: Messina, Antonietta, et al.
Publicado: (2020) -
Human Pluripotent Stem Cell-Derived Hepatocyte-Like Cells and Organoids for Liver Disease and Therapy
por: Li, Yang, et al.
Publicado: (2021) -
Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids
por: Jeong, Jaemin, et al.
Publicado: (2022) -
Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes
por: Zahmatkesh, Ensieh, et al.
Publicado: (2021)