Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system

The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden. In most pati...

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Detalles Bibliográficos
Autores principales: Lhuillier, Claire, Rudqvist, Nils-Petter, Elemento, Olivier, Formenti, Silvia C., Demaria, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587285/
https://www.ncbi.nlm.nih.gov/pubmed/31221199
http://dx.doi.org/10.1186/s13073-019-0653-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587285/
https://www.ncbi.nlm.nih.gov/pubmed/31221199
http://dx.doi.org/10.1186/s13073-019-0653-7

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