Application of Physiologically Based Pharmacokinetic Modeling to Predict Pharmacokinetics in Healthy Japanese Subjects

Pharmacokinetics (PKs) in Japanese healthy subjects were simulated for nine compounds using physiologically based PK (PBPK) models parameterized with physicochemical properties, preclinical absorption, distribution, metabolism, and excretion (ADME) data, and clinical PK data from non‐Japanese subjec...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumoto, Yuki, Cabalu, Tamara, Sandhu, Punam, Hartmann, Georgy, Iwasa, Takashi, Yoshitsugu, Hiroyuki, Gibson, Christopher, Uemura, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587435/
https://www.ncbi.nlm.nih.gov/pubmed/30252941
http://dx.doi.org/10.1002/cpt.1240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587435/
https://www.ncbi.nlm.nih.gov/pubmed/30252941
http://dx.doi.org/10.1002/cpt.1240

Ejemplares similares