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Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-...

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Autores principales: Darby, Matthew G., Chetty, Alisha, Mrjden, Dunja, Rolot, Marion, Smith, Katherine, Mackowiak, Claire, Sedda, Delphine, Nyangahu, Donald, Jaspan, Heather, Toellner, Kai-Michael, Waisman, Ari, Quesniaux, Valerie, Ryffel, Bernhard, Cunningham, Adam F., Dewals, Benjamin G., Brombacher, Frank, Horsnell, William G. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587632/
https://www.ncbi.nlm.nih.gov/pubmed/31236458
http://dx.doi.org/10.1126/sciadv.aav3058
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author Darby, Matthew G.
Chetty, Alisha
Mrjden, Dunja
Rolot, Marion
Smith, Katherine
Mackowiak, Claire
Sedda, Delphine
Nyangahu, Donald
Jaspan, Heather
Toellner, Kai-Michael
Waisman, Ari
Quesniaux, Valerie
Ryffel, Bernhard
Cunningham, Adam F.
Dewals, Benjamin G.
Brombacher, Frank
Horsnell, William G. C.
author_facet Darby, Matthew G.
Chetty, Alisha
Mrjden, Dunja
Rolot, Marion
Smith, Katherine
Mackowiak, Claire
Sedda, Delphine
Nyangahu, Donald
Jaspan, Heather
Toellner, Kai-Michael
Waisman, Ari
Quesniaux, Valerie
Ryffel, Bernhard
Cunningham, Adam F.
Dewals, Benjamin G.
Brombacher, Frank
Horsnell, William G. C.
author_sort Darby, Matthew G.
collection PubMed
description Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (T(H)2) impaired IL-4Rα(−/−) offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived T(H)2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.
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spelling pubmed-65876322019-06-24 Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring Darby, Matthew G. Chetty, Alisha Mrjden, Dunja Rolot, Marion Smith, Katherine Mackowiak, Claire Sedda, Delphine Nyangahu, Donald Jaspan, Heather Toellner, Kai-Michael Waisman, Ari Quesniaux, Valerie Ryffel, Bernhard Cunningham, Adam F. Dewals, Benjamin G. Brombacher, Frank Horsnell, William G. C. Sci Adv Research Articles Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (T(H)2) impaired IL-4Rα(−/−) offspring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived T(H)2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes. American Association for the Advancement of Science 2019-05-29 /pmc/articles/PMC6587632/ /pubmed/31236458 http://dx.doi.org/10.1126/sciadv.aav3058 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Darby, Matthew G.
Chetty, Alisha
Mrjden, Dunja
Rolot, Marion
Smith, Katherine
Mackowiak, Claire
Sedda, Delphine
Nyangahu, Donald
Jaspan, Heather
Toellner, Kai-Michael
Waisman, Ari
Quesniaux, Valerie
Ryffel, Bernhard
Cunningham, Adam F.
Dewals, Benjamin G.
Brombacher, Frank
Horsnell, William G. C.
Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
title Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
title_full Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
title_fullStr Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
title_full_unstemmed Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
title_short Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
title_sort pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587632/
https://www.ncbi.nlm.nih.gov/pubmed/31236458
http://dx.doi.org/10.1126/sciadv.aav3058
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