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An update on adaptive deep brain stimulation in Parkinson's disease
Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatment. Closed‐loop or adaptive DBS aims to overcome these limit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587997/ https://www.ncbi.nlm.nih.gov/pubmed/30357911 http://dx.doi.org/10.1002/mds.115 |
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author | Habets, Jeroen G.V. Heijmans, Margot Kuijf, Mark L. Janssen, Marcus L.F. Temel, Yasin Kubben, Pieter L. |
author_facet | Habets, Jeroen G.V. Heijmans, Margot Kuijf, Mark L. Janssen, Marcus L.F. Temel, Yasin Kubben, Pieter L. |
author_sort | Habets, Jeroen G.V. |
collection | PubMed |
description | Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatment. Closed‐loop or adaptive DBS aims to overcome these limitations by real‐time adjustment of stimulation parameters based on continuous feedback input signals that are representative of the patient's clinical state. The focus of this update is to discuss the most recent developments regarding potential input signals and possible stimulation parameter modulation for adaptive DBS in PD. Potential input signals for adaptive DBS include basal ganglia local field potentials, cortical recordings (electrocorticography), wearable sensors, and eHealth and mHealth devices. Furthermore, adaptive DBS can be applied with different approaches of stimulation parameter modulation, the feasibility of which can be adapted depending on specific PD phenotypes. Implementation of technological developments like machine learning show potential in the design of such approaches; however, energy consumption deserves further attention. Furthermore, we discuss future considerations regarding the clinical implementation of adaptive DBS in PD. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. |
format | Online Article Text |
id | pubmed-6587997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65879972019-07-02 An update on adaptive deep brain stimulation in Parkinson's disease Habets, Jeroen G.V. Heijmans, Margot Kuijf, Mark L. Janssen, Marcus L.F. Temel, Yasin Kubben, Pieter L. Mov Disord Reviews Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatment. Closed‐loop or adaptive DBS aims to overcome these limitations by real‐time adjustment of stimulation parameters based on continuous feedback input signals that are representative of the patient's clinical state. The focus of this update is to discuss the most recent developments regarding potential input signals and possible stimulation parameter modulation for adaptive DBS in PD. Potential input signals for adaptive DBS include basal ganglia local field potentials, cortical recordings (electrocorticography), wearable sensors, and eHealth and mHealth devices. Furthermore, adaptive DBS can be applied with different approaches of stimulation parameter modulation, the feasibility of which can be adapted depending on specific PD phenotypes. Implementation of technological developments like machine learning show potential in the design of such approaches; however, energy consumption deserves further attention. Furthermore, we discuss future considerations regarding the clinical implementation of adaptive DBS in PD. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. John Wiley and Sons Inc. 2018-10-24 2018-12 /pmc/articles/PMC6587997/ /pubmed/30357911 http://dx.doi.org/10.1002/mds.115 Text en © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Habets, Jeroen G.V. Heijmans, Margot Kuijf, Mark L. Janssen, Marcus L.F. Temel, Yasin Kubben, Pieter L. An update on adaptive deep brain stimulation in Parkinson's disease |
title | An update on adaptive deep brain stimulation in Parkinson's disease |
title_full | An update on adaptive deep brain stimulation in Parkinson's disease |
title_fullStr | An update on adaptive deep brain stimulation in Parkinson's disease |
title_full_unstemmed | An update on adaptive deep brain stimulation in Parkinson's disease |
title_short | An update on adaptive deep brain stimulation in Parkinson's disease |
title_sort | update on adaptive deep brain stimulation in parkinson's disease |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587997/ https://www.ncbi.nlm.nih.gov/pubmed/30357911 http://dx.doi.org/10.1002/mds.115 |
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