Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling

Missense mutations in the human TUBB3 gene cause a variety of neurological disorders associated with defects in axon guidance and neuronal migration, but the underlying molecular mechanisms are not well understood. Recent studies have shown that direct coupling of dynamic TUBB3 in microtubules with...

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Detalles Bibliográficos
Autores principales: Shao, Qiangqiang, Yang, Tao, Huang, Huai, Majumder, Tanushree, Khot, Bhakti Ajit, Khouzani, Mohammad Masoudian, Alarmanazi, Farrah, Gore, Yasmin K., Liu, Guofa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588280/
https://www.ncbi.nlm.nih.gov/pubmed/31226147
http://dx.doi.org/10.1371/journal.pone.0218811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588280/
https://www.ncbi.nlm.nih.gov/pubmed/31226147
http://dx.doi.org/10.1371/journal.pone.0218811

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