Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

The unfolded protein response (UPR) detects and restores deficits in the endoplasmic reticulum (ER) protein folding capacity. Ceapins specifically inhibit the UPR sensor ATF6α, an ER-tethered transcription factor, by retaining it at the ER through an unknown mechanism. Our genome-wide CRISPR interfe...

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Detalles Bibliográficos
Autores principales: Torres, Sandra Elizabeth, Gallagher, Ciara M, Plate, Lars, Gupta, Meghna, Liem, Christina R, Guo, Xiaoyan, Tian, Ruilin, Stroud, Robert M, Kampmann, Martin, Weissman, Jonathan S, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588346/
https://www.ncbi.nlm.nih.gov/pubmed/31149896
http://dx.doi.org/10.7554/eLife.46595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588346/
https://www.ncbi.nlm.nih.gov/pubmed/31149896
http://dx.doi.org/10.7554/eLife.46595

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