The deubiquitinase Otub1 controls the activation of CD8 T cells and NK cells by regulating IL-15-mediated priming

CD8 T cells and natural killer (NK) cells, central cellular components of immune responses against pathogens and cancer, rely on IL-15 for homeostasis. Here we show that IL-15 also mediates homeostatic priming of CD8 T cells for antigen-stimulated activation, which is controlled by a deubiquitinase,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Xiaofei, Yu, Jiayi, Cheng, Xuhong, Zhao, Baoyu, Manyam, Ganiraju C, Zhang, Li, Schluns, Kimberly, Li, Pingwei, Wang, Jing, Sun, Shao-Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588407/
https://www.ncbi.nlm.nih.gov/pubmed/31182807
http://dx.doi.org/10.1038/s41590-019-0405-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588407/
https://www.ncbi.nlm.nih.gov/pubmed/31182807
http://dx.doi.org/10.1038/s41590-019-0405-2

Ejemplares similares