The IRE1 ER stress sensor activates natural killer cell immunity in part by regulating c-Myc

Natural killer (NK) cells are critical mediators of host immunity to pathogens. Here, we demonstrate that the ER stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo....

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Detalles Bibliográficos
Autores principales: Dong, Han, Adams, Nicholas M., Xu, Yichi, Cao, Jin, Allan, David S.J., Carlyle, James R., Chen, Xi, Sun, Joseph C., Glimcher, Laurie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588410/
https://www.ncbi.nlm.nih.gov/pubmed/31086333
http://dx.doi.org/10.1038/s41590-019-0388-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588410/
https://www.ncbi.nlm.nih.gov/pubmed/31086333
http://dx.doi.org/10.1038/s41590-019-0388-z

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