Feasibility of Using NF1-GRD and AAV for Gene Replacement Therapy in NF1-Associated Tumors

Neurofibromatosis type 1, including the highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), is featured by the loss of functional neurofibromin 1 (NF1) protein resulting from genetic alterations. A major function of NF1 is suppressing Ras activities, which is conveyed by an intrinsi...

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Detalles Bibliográficos
Autores principales: Bai, Ren-Yuan, Esposito, Dominic, Tam, Ada J., McCormick, Frank, Riggins, Gregory J., Clapp, D. Wade, Staedtke, Verena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588423/
https://www.ncbi.nlm.nih.gov/pubmed/31127187
http://dx.doi.org/10.1038/s41434-019-0080-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588423/
https://www.ncbi.nlm.nih.gov/pubmed/31127187
http://dx.doi.org/10.1038/s41434-019-0080-9

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