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Feasibility of Using NF1-GRD and AAV for Gene Replacement Therapy in NF1-Associated Tumors
Neurofibromatosis type 1, including the highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), is featured by the loss of functional neurofibromin 1 (NF1) protein resulting from genetic alterations. A major function of NF1 is suppressing Ras activities, which is conveyed by an intrinsi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588423/ https://www.ncbi.nlm.nih.gov/pubmed/31127187 http://dx.doi.org/10.1038/s41434-019-0080-9 |