Integrative inference of subclonal tumour evolution from single-cell and bulk sequencing data

Understanding the clonal architecture and evolutionary history of a tumour poses one of the key challenges to overcome treatment failure due to resistant cell populations. Previously, studies on subclonal tumour evolution have been primarily based on bulk sequencing and in some recent cases on singl...

Descripción completa

Detalles Bibliográficos
Autores principales: Malikic, Salem, Jahn, Katharina, Kuipers, Jack, Sahinalp, S. Cenk, Beerenwinkel, Niko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588593/
https://www.ncbi.nlm.nih.gov/pubmed/31227714
http://dx.doi.org/10.1038/s41467-019-10737-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588593/
https://www.ncbi.nlm.nih.gov/pubmed/31227714
http://dx.doi.org/10.1038/s41467-019-10737-5

Ejemplares similares