Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets

Development of drugs that allosterically regulate enzyme functions to treat disease is a costly venture. Amino acid susbstitutions that mimic allosteric effectors in vitro will identify therapeutic regulatory targets enhancing the likelihood of developing a disease treatment at a reasonable cost. We...

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Detalles Bibliográficos
Autores principales: Tang, Qingling, Villar, Maria T., Artigues, Antonio, Thyfault, John P., Apte, Udayan, Zhu, Hao, Peterson, Kenneth R., Fenton, Aron W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588628/
https://www.ncbi.nlm.nih.gov/pubmed/31227746
http://dx.doi.org/10.1038/s41598-019-45202-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588628/
https://www.ncbi.nlm.nih.gov/pubmed/31227746
http://dx.doi.org/10.1038/s41598-019-45202-2

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