E2F1 mediates the downregulation of POLD1 in replicative senescence

POLD1, the catalytic subunit of DNA Pol δ, plays an important role in DNA synthesis and DNA damage repair, and POLD1 is downregulated in replicative senescence and mediates cell aging. However, the mechanisms of age-related downregulation of POLD1 expression have not been elucidated. In this study,...

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Detalles Bibliográficos
Autores principales: Gao, Shichao, Song, Qiao, Liu, Jing, Zhang, Xiaomin, Ji, Xunming, Wang, Peichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588650/
https://www.ncbi.nlm.nih.gov/pubmed/30895337
http://dx.doi.org/10.1007/s00018-019-03070-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588650/
https://www.ncbi.nlm.nih.gov/pubmed/30895337
http://dx.doi.org/10.1007/s00018-019-03070-z

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