Ketogenic treatment reduces the percentage of a LHON heteroplasmic mutation and increases mtDNA amount of a LHON homoplasmic mutation

BACKGROUND: The vision loss in Leber hereditary optic neuropathy patients is due to mitochondrial DNA mutations. No treatment has shown a clear-cut benefit on a clinically meaningful end-point. However, clinical evidences suggest two therapeutic approaches: the reduction of the mutation load in hete...

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Detalles Bibliográficos
Autores principales: Emperador, Sonia, López-Gallardo, Ester, Hernández-Ainsa, Carmen, Habbane, Mouna, Montoya, Julio, Bayona-Bafaluy, M. Pilar, Ruiz-Pesini, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588889/
https://www.ncbi.nlm.nih.gov/pubmed/31226990
http://dx.doi.org/10.1186/s13023-019-1128-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588889/
https://www.ncbi.nlm.nih.gov/pubmed/31226990
http://dx.doi.org/10.1186/s13023-019-1128-z

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