Cargando…

Power estimations for non-primary outcomes in randomised clinical trials

Objective and methods: It is rare that trialists report power estimations of non-primary outcomes. In the present article, we will describe how to define a valid hierarchy of outcomes in a randomised clinical trial, to limit problems with Type I and Type II errors, using considerations on the clinic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jakobsen, Janus Christian, Ovesen, Christian, Winkel, Per, Hilden, Jørgen, Gluud, Christian, Wetterslev, Jørn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Research Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588976/ https://www.ncbi.nlm.nih.gov/pubmed/31175197 http://dx.doi.org/10.1136/bmjopen-2018-027092

Ejemplares similares

When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts
por: Jakobsen, Janus Christian, et al.
Publicado: (2017)

The thresholds for statistical and clinical significance – a five-step procedure for evaluation of intervention effects in randomised clinical trials
por: Jakobsen, Janus Christian, et al.
Publicado: (2014)

Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods
por: Jakobsen, Janus Christian, et al.
Publicado: (2014)

Trial Sequential Analysis in systematic reviews with meta-analysis
por: Wetterslev, Jørn, et al.
Publicado: (2017)

Predictors for major cardiovascular outcomes in stable ischaemic heart disease (PREMAC): statistical analysis plan for data originating from the CLARICOR (clarithromycin for patients with stable coronary heart disease) trial
por: Winkel, Per, et al.
Publicado: (2017)

Prothrombin complex concentrate versus placebo, no intervention, or other interventions in critically bleeding patients associated with oral anticoagulant administration: a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
por: Ovesen, Christian, et al.
Publicado: (2018)

Prognostic value of routinely available data in patients with stable coronary heart disease. A 10-year follow-up of patients sampled at random times during their disease course
por: Winkel, Per, et al.
Publicado: (2018)

Third-wave cognitive therapy versus mentalisation-based treatment for major depressive disorder: a randomised clinical trial
por: Jakobsen, Janus Christian, et al.
Publicado: (2014)

Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease. A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial
por: Winkel, Per, et al.
Publicado: (2020)

‘Third wave’ cognitive therapy versus mentalization-based therapy for major depressive disorder. A protocol for a randomised clinical trial
por: Jakobsen, Janus Christian, et al.
Publicado: (2012)

10‐Year Associations Between Tumor Necrosis Factor Receptors 1 and 2 and Cardiovascular Events in Patients With Stable Coronary Heart Disease: A CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) Trial Substudy
por: Carlsson, Axel C., et al.
Publicado: (2018)

Estimating required information size by quantifying diversity in random-effects model meta-analyses
por: Wetterslev, Jørn, et al.
Publicado: (2009)

Effect of Chronic Escitalopram versus Placebo on Personality Traits in Healthy First-Degree Relatives of Patients with Depression: A Randomized Trial
por: Knorr, Ulla, et al.
Publicado: (2012)

Statistical analysis plan: Early mobilization by head-up tilt with stepping versus standard care after severe traumatic brain injury
por: Riberholt, Christian Gunge, et al.
Publicado: (2021)

Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
por: Hemmingsen, Bianca, et al.
Publicado: (2011)

Prognosis and Reclassification by YKL‐40 in Stable Coronary Artery Disease
por: Schroder, Jakob, et al.
Publicado: (2020)

Social-Skills and Parental Training plus Standard Treatment versus Standard Treatment for Children with ADHD – The Randomised SOSTRA Trial
por: Storebø, Ole Jakob, et al.
Publicado: (2012)

False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review
por: Imberger, Georgina, et al.
Publicado: (2016)

Targeting intensive versus conventional glycaemic control for type 1 diabetes mellitus: a systematic review with meta-analyses and trial sequential analyses of randomised clinical trials
por: Kähler, Pernille, et al.
Publicado: (2014)

The Effects of Centralised and Specialised Intervention in the Early Course of Severe Unipolar Depressive Disorder: A Randomised Clinical Trial
por: Hansen, Hanne Vibe, et al.
Publicado: (2012)

Escitalopram and Neuroendocrine Response in Healthy First-Degree Relatives to Depressed Patients – A Randomized Placebo-Controlled Trial
por: Knorr, Ulla, et al.
Publicado: (2011)

Deep brain stimulation for neurological disorders: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
por: Petersen, Johanne Juul, et al.
Publicado: (2022)

Carotid endarterectomy with primary closure versus patch angioplasty in patients with symptomatic and significant stenosis: protocol for a systematic review with meta-analyses and trial sequential analysis of randomised clinical trials
por: Marsman, Martijn S, et al.
Publicado: (2019)

The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders - design of two randomised clinical trials
por: Kessing, Lars Vedel, et al.
Publicado: (2011)

Milrinone for cardiac dysfunction in critically ill adult patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
por: Koster, Geert, et al.
Publicado: (2016)

Dopamine in critically ill patients with cardiac dysfunction: A systematic review with meta‐analysis and trial sequential analysis
por: Hiemstra, Bart, et al.
Publicado: (2018)

Central data monitoring in the multicentre randomised SafeBoosC-III trial – a pragmatic approach
por: Olsen, Markus Harboe, et al.
Publicado: (2021)

Early Orthostatic Exercise by Head-Up Tilt With Stepping vs. Standard Care After Severe Traumatic Brain Injury Is Feasible
por: Riberholt, Christian Gunge, et al.
Publicado: (2021)

Health apps targeting children with overweight—a protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
por: Rashid, Rajeeb, et al.
Publicado: (2020)

Digoxin for atrial fibrillation and atrial flutter: A systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
por: Sethi, Naqash J., et al.
Publicado: (2018)

Duloxetine versus ‘active’ placebo, placebo or no intervention for major depressive disorder; a protocol for a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
por: Siddiqui, Faiza, et al.
Publicado: (2021)

Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial
por: Ovesen, Christian, et al.
Publicado: (2018)

Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
por: Jørgensen, Caroline Kamp, et al.
Publicado: (2022)

Carotid endarterectomy with patch angioplasty versus primary closure in patients with symptomatic and significant stenosis: a systematic review with meta-analyses and trial sequential analysis of randomized clinical trials
por: Marsman, Martijn S., et al.
Publicado: (2021)

Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis
por: Maagaard, Mathias, et al.
Publicado: (2020)

Quality of life, patient satisfaction, and cardiovascular outcomes of the randomised 2 x 3 factorial Copenhagen insulin and Metformin therapy (CIMT) trial – A detailed statistical analysis plan
por: Olsen, Markus Harboe, et al.
Publicado: (2023)

PANSAID—PAracetamol and NSAID in combination: detailed statistical analysis plan for a randomised, blinded, parallel, four-group multicentre clinical trial
por: Thybo, Kasper Højgaard, et al.
Publicado: (2017)

Randomised social-skills training and parental training plus standard treatment versus standard treatment of children with attention deficit hyperactivity disorder - The SOSTRA trial protocol
por: Storebø, Ole Jakob, et al.
Publicado: (2011)

Internet-based self-help therapy with FearFighter™ versus no intervention for anxiety disorders in adults: study protocol for a randomised controlled trial
por: Fenger, Morten, et al.
Publicado: (2016)

Should antidepressants be used for major depressive disorder?
por: Jakobsen, Janus Christian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_80g26g6eg8jo6l26mmkhf5acaf