Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization

Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression by facilitating cell movement through physically constraining environments. To identify properties that enabled passage through physical con...

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Detalles Bibliográficos
Autores principales: Rudzka, Dominika A., Spennati, Giulia, McGarry, David J., Chim, Ya-Hua, Neilson, Matthew, Ptak, Aleksandra, Munro, June, Kalna, Gabriela, Hedley, Ann, Moralli, Daniela, Green, Catherine, Mason, Susan, Blyth, Karen, Mullin, Margaret, Yin, Huabing, Olson, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589089/
https://www.ncbi.nlm.nih.gov/pubmed/31152052
http://dx.doi.org/10.1242/jcs.224071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589089/
https://www.ncbi.nlm.nih.gov/pubmed/31152052
http://dx.doi.org/10.1242/jcs.224071

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