Cargando…

MIR29B mediates epigenetic mechanisms of HBG gene activation

Sickle cell disease (SCD) affects over 2 million people worldwide with high morbidity and mortality in underdeveloped countries. Therapeutic interventions aimed at reactivating fetal haemoglobin (HbF) is an effective approach for improving survival and ameliorating the clinical severity of SCD. A cl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Starlard‐Davenport, Athena, Smith, Alana, Vu, Luan, Li, Biaoru, Pace, Betty S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Red Cells and Iron
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589104/ https://www.ncbi.nlm.nih.gov/pubmed/30891745 http://dx.doi.org/10.1111/bjh.15870

Ejemplares similares

Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option
por: Starlard-Davenport, Athena, et al.
Publicado: (2022)

Heterozygosity for bisphosphoglycerate mutase deficiency expressing clinically as congenital erythrocytosis: A case series and literature review
por: van Dijk, Myrthe J., et al.
Publicado: (2022)

MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice
por: Gu, Qingqing, et al.
Publicado: (2022)

Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia
por: Kumkhaek, Chutima, et al.
Publicado: (2008)

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease
por: Vichinsky, Elliott, et al.
Publicado: (2007)

Long-term safety and efficacy of deferasirox (Exjade®) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease
por: Vichinsky, Elliott, et al.
Publicado: (2011)

Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises
por: Krishnan, Suba, et al.
Publicado: (2010)

Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia
por: Uyoga, Sophie, et al.
Publicado: (2012)

Efficacy and safety of deferasirox doses of >30 mg/kg per d in patients with transfusion-dependent anaemia and iron overload
por: Taher, Ali, et al.
Publicado: (2009)

Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness
por: Makani, Julie, et al.
Publicado: (2009)

Haptoglobin, alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania
por: Cox, Sharon E., et al.
Publicado: (2014)

Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection
por: Cserti-Gazdewich, Christine M, et al.
Publicado: (2012)

Epistasis and the sensitivity of phenotypic screens for beta thalassaemia
por: Penman, Bridget S, et al.
Publicado: (2015)

Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
por: Makani, Julie, et al.
Publicado: (2015)

The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels
por: Patel, Neeta, et al.
Publicado: (2014)

An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin
por: Carrancio, Soraya, et al.
Publicado: (2014)

Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co-express gamma and beta globins
por: Yang, Cheng-Tao, et al.
Publicado: (2014)

A novel 33‐Gene targeted resequencing panel provides accurate, clinical‐grade diagnosis and improves patient management for rare inherited anaemias
por: Roy, Noémi B. A., et al.
Publicado: (2016)

Iron overload across the spectrum of non‐transfusion‐dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions
por: Porter, John B., et al.
Publicado: (2016)

Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia
por: Hannemann, Anke, et al.
Publicado: (2018)

Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities
por: Miller, Robin E., et al.
Publicado: (2019)

Ticagrelor does not impact patient‐reported pain in young adults with sickle cell disease: a multicentre, randomised phase IIb study
por: Kanter, Julie, et al.
Publicado: (2018)

Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10‐year pharmacovigilance analysis
por: Socié, Gérard, et al.
Publicado: (2019)

Safety and benefits of interventions to increase folate status in malaria‐endemic areas
por: Verhoef, Hans, et al.
Publicado: (2017)

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review
por: Mwangi, Martin N., et al.
Publicado: (2017)

Deficit of circulating CD19(+)CD24(hi)CD38(hi) regulatory B cells in severe aplastic anaemia
por: Zaimoku, Yoshitaka, et al.
Publicado: (2020)

Efficacy and safety of romiplostim in refractory aplastic anaemia: a Phase II/III, multicentre, open‐label study
por: Jang, Jun Ho, et al.
Publicado: (2020)

Pharmacokinetic and pharmacodynamic effects of ravulizumab and eculizumab on complement component 5 in adults with paroxysmal nocturnal haemoglobinuria: results of two phase 3 randomised, multicentre studies
por: Peffault de Latour, Régis, et al.
Publicado: (2020)

Distinctive and common features of moderate aplastic anaemia
por: Patel, Bhumika J., et al.
Publicado: (2020)

Vasculo‐toxic and pro‐inflammatory action of unbound haemoglobin, haem and iron in transfusion‐dependent patients with haemolytic anaemias
por: Vinchi, Francesca, et al.
Publicado: (2021)

Measurement of erythrocyte membrane mannoses to assess splenic function
por: Cao, Huan, et al.
Publicado: (2022)

Germline ERCC excision repair 6 like 2 ( ERCC6L2 ) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
por: Armes, Hannah, et al.
Publicado: (2022)

Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleation
por: An, Chao, et al.
Publicado: (2021)

Structural connectivity mediates the relationship between blood oxygenation and cognitive function in sickle cell anemia
por: Clayden, Jonathan D., et al.
Publicado: (2022)

Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function
por: Zhou, Yichao, et al.
Publicado: (2023)

Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis
por: Liang, Raymond, et al.
Publicado: (2023)

Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis
por: Narla, Anupama, et al.
Publicado: (2011)

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
por: Prentice, Andrew M., et al.
Publicado: (2012)

A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax
por: Russell, Bruce, et al.
Publicado: (2011)

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation
por: Jiang, Li, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b3c2st2k5dl11ds82ei3attf8m