Selective defects in gene expression control genome instability in yeast splicing mutants

RNA processing mutants have been broadly implicated in genome stability, but mechanistic links are often unclear. Two predominant models have emerged: one involving changes in gene expression that perturb other genome maintenance factors and another in which genotoxic DNA:RNA hybrids, called R-loops...

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Detalles Bibliográficos
Autores principales: Tam, Annie S., Sihota, Tianna S., Milbury, Karissa L., Zhang, Anni, Mathew, Veena, Stirling, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589566/
https://www.ncbi.nlm.nih.gov/pubmed/30462576
http://dx.doi.org/10.1091/mbc.E18-07-0439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589566/
https://www.ncbi.nlm.nih.gov/pubmed/30462576
http://dx.doi.org/10.1091/mbc.E18-07-0439

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