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Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of...

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Detalles Bibliográficos
Autores principales: Bian, Jifeng, Christiansen, Jeffrey R., Moreno, Julie A., Kane, Sarah J., Khaychuk, Vadim, Gallegos, Joseph, Kim, Sehun, Telling, Glenn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589652/
https://www.ncbi.nlm.nih.gov/pubmed/31147460
http://dx.doi.org/10.1073/pnas.1903947116