Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα(+)) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine transporter, SNAT2, is the AA transporter most fr...

Descripción completa

Detalles Bibliográficos
Autores principales: Morotti, Matteo, Bridges, Esther, Valli, Alessandro, Choudhry, Hani, Sheldon, Helen, Wigfield, Simon, Gray, Nicki, Zois, Christos E., Grimm, Fiona, Jones, Dylan, Teoh, Eugene J., Cheng, Wei-Chen, Lord, Simon, Anastasiou, Dimitrios, Haider, Syed, McIntyre, Alan, Goberdhan, Deborah C. I., Buffa, Francesca, Harris, Adrian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589752/
https://www.ncbi.nlm.nih.gov/pubmed/31152137
http://dx.doi.org/10.1073/pnas.1818521116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589752/
https://www.ncbi.nlm.nih.gov/pubmed/31152137
http://dx.doi.org/10.1073/pnas.1818521116

Ejemplares similares