Mechanosensitive Rap1 activation promotes barrier function of lung vascular endothelium under cyclic stretch

Mechanical ventilation remains an imperative treatment for the patients with acute respiratory distress syndrome, but can also exacerbate lung injury. We have previously described a key role of RhoA GTPase in high cyclic stretch (CS)–induced endothelial cell (EC) barrier dysfunction. However, cellul...

Descripción completa

Detalles Bibliográficos
Autores principales: Ke, Yunbo, Karki, Pratap, Zhang, Chenou, Li, Yue, Nguyen, Trang, Birukov, Konstantin G., Birukova, Anna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589902/
https://www.ncbi.nlm.nih.gov/pubmed/30759056
http://dx.doi.org/10.1091/mbc.E18-07-0422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589902/
https://www.ncbi.nlm.nih.gov/pubmed/30759056
http://dx.doi.org/10.1091/mbc.E18-07-0422

Ejemplares similares